Have you ever encountered this situation?

A cup of coffee

Keeps you awake late at night,

Tossing and turning

“Counting sheep” doesn’t work either.

Why?

Why can some people drink coffee but some can't? What is the reason? Let's talk about this topic today.

Ingredients of coffee.

Coffee contains a stimulating ingredient - caffeine, a fat-soluble alkaloid. It needs to be detoxified by the liver before it can be metabolized. Only after metabolism will it no longer make people excited.

How does the liver metabolize caffeine?

Cytochrome P450 enzyme system.

Are all cytochrome P450 enzymes the same?

The cytochrome oxidase P450 (especially the 1A2 isozyme) enzyme system, especially the CYP1A2 gene, is responsible for clearing caffeine from the body. Because the gene for this enzyme is polymorphic, the efficiency of this clearance varies from person to person.

What does the liver do?

The liver is the largest substantial organ in the human body and also the largest gland in the body. It has abundant organelles (such as endoplasmic reticulum, mitochondria and lysosomes) and enzyme systems (such as peroxidase system), so the liver has powerful functions of material metabolism, biotransformation, secretion and excretion, that is, "detoxification". In other words, harmful components in food, beverages and other substances need to be metabolized by the liver before they can become harmless components.

How to metabolize?

In order for fat-soluble substances to be excreted from the body, they need to undergo an enzyme-catalyzed metabolic transformation process to increase their water solubility, enhance their polarity, and make them easier to excrete through bile or urine. This metabolic mechanism is called biotransformation or detoxification process.

Do you understand? Everyone's metabolic enzymes are different.

If some people metabolize this enzyme quickly, the caffeine they consume will be cleared out of the body very quickly, so the effect of caffeine is very limited and it cannot make people feel particularly excited. For others, their enzyme metabolism is slow, and the caffeine is cleared from the body very slowly, so it takes a long time to work. Such people often can't sleep at night after drinking a cup of coffee, and some may even affect their appetite, vomit and cramp, and may also have adverse reactions such as gastritis or heart disease. Therefore, a cup of coffee or a cup of tea can keep some people "sleepless all night."

What to do?

The genetic difference of detoxification enzymes is innate. We can eat more foods that help the liver detoxify (such as cruciferous vegetables, dark fruits such as blueberries, black garlic, etc.), and reduce the intake of these "substances". Reduce the burden on the liver and reduce the impact on the human body.

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